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April 1, 1997Synthesis

An Efficient, Scaleable Procedure for the Conversion of Esters to Isoxazoles

William H. Bunnelle Pulla Reddy Singam B. A. Narayanan Curt W. Bradshaw Jia‐Lun Liou

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Abstract

All articles of this category A concise, regiocontrolled route to isoxazoles, based on the condensation of an ester with a metallated imine, has been developed. The intermediate vinylogous amides react smoothly with hydroxylamine to provide, after dehydration, substituted isoxazoles. The method has been used for the multi-kilo scale preparation of ABT-418, a novel cholinergic channel activator. Regiocontrolled isoxazole synthesis via condensation of ester with metallated imine

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Cite This Study

Bunnelle et al. (1997) studied this question.

synapsesocial.com/papers/6aa925f19965218ad462dff1 https://doi.org/10.1055/s-1997-1211

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