Key result
FGF-2 represses collagen production and activates fiber degradation via MMP-1 in human vascular SMCs.
Why the study?
The influence of fibroblast growth factor-2 on collagen fiber remodeling by human vascular smooth muscle cells is not well understood.
Does FGF-2 alter the expression of collagens and matrix metalloproteinases in cultured human vascular smooth muscle cells?
Population
Cultured human vascular smooth muscle cells
Comparison
Fibroblast growth factor-2 stimulation vs basal culture conditions
Design
Preclinical experimental study
Authors
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FGF-2 may promote plaque vulnerability; hypothesis-generating for vascular remodeling in atherosclerosis.
Does FGF-2 alter the expression of collagens and matrix metalloproteinases in cultured human vascular smooth muscle cells?
FGF-2 stimulation of human vascular smooth muscle cells represses collagen production and activates collagen degradation, a mechanism potentially critical for vascular remodeling and atherosclerotic plaque destabilization.
Pickering et al. (1997) studied this question. Fibroblast growth factor-2 (FGF-2) vs. Unstimulated SMCs / basal culture conditions was evaluated on Expression of fibrillar collagens, matrix metalloproteinases (MMPs), and tissue inhibitors of MMPs (TIMPs). Stimulation of human vascular smooth muscle cells with FGF-2 represses collagen fiber production and activates the capacity for fiber degradation via MMP-1 induction.
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