Triazole Biheterocycles from Cinchona Alkaloids: Coordination and Antiproliferative Properties

Eighteen new copper‐complexing derivatives of Cinchona alkaloids entailing 1,2,3‐triazole rings connected to pyridine, pyrimidine and quinoline were obtained in Sonogashira and 1,3‐dipolar cycloaddition reactions. The compounds were tested in an antiproliferative assay against five different cancer cell lines and those containing quinoline‐triazole system exhibited pronounced inhibitory effect comparable, or exceeding that of cisplatin. Quinine derivative substituted at position 2’ with triazolyl‐phenol moiety showed promising selectivity against HT‐29 colon cancer cell line (IC 50 0.65 μg/mL).