Total Synthesis of (±)-Phytochromobilin Starting from Two Pyrrole Derivatives

All articles of this category (±)-Phytochromobilin was synthesized as an acid form by developing a convenient method for the preparation of A- and D-rings starting from a 2-tosylpyrrole derivative, followed by efficient construction of A/B- and C/D-ring components via Wittig-type coupling reaction of 5-tosylpyrrolinones with 2-formylpyrrole, and palladium catalyzed deprotection of allyl esters of propanoic acid side chains of C-8 and C-12. phytochrome - tetrapyrrole - phytochromobilin - total synthesis - transformation of pyrroles