Key result
TNF-α and IL-6 may be essential for nutritional sensing and homeostasis in normal adipose tissue.
Why the study?
The role of inflammatory cytokines such as TNF-α in normal adipose tissue function and homeostasis in lean, healthy subjects is unclear.
Answers are grounded in this paper and cite their sources.
Does not alter metabolic disease management; leaves open therapeutic relevance of TNFα/IL-6 in adipose dysfunction.
To the Editor: In patients with obesity, adipose tissue is characterized by low-grade inflammation and increased secretion of several cytokines.1 Tumor necrosis factor α (TNF-α) and interleukin-6 may be most pernicious, since they alter adipose-tissue function, influence adipogenesis, and are involved in the metabolic complications of obesity.1 However, adipose inflammatory cytokines may be not only culprits but also important players in normal adipose-tissue function, since inflammation may be essential for sensing nutritional needs and maintaining homeostasis in adipose tissue.2 If this is true, there should be a relationship between cytokine release and characteristics of adipose tissue in lean, healthy subjects. . . .
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Rydén et al. (2010) conducted a letter in Obesity and normal adipose-tissue function. Tumor necrosis factor α (TNF-α) and interleukin-6 was evaluated. Tumor necrosis factor α and interleukin-6 may be essential for sensing nutritional needs and maintaining homeostasis in normal adipose tissue.
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