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January 1, 2004Archives of Neurology

Safety of Latest-Generation Self-expanding Stents in Patients With NASCET-Ineligible Severe Symptomatic Extracranial Internal Carotid Artery Stenosis

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Key result

Latest-generation CAS yields a ~9% 6-month stroke or death rate in patients ineligible for endarterectomy.

  • n=23

Why the study?

Does carotid angioplasty and stenting with latest-generation self-expanding stents provide a safe alternative in patients with symptomatic extracranial internal carotid artery stenosis who are ineligible for carotid endarterectomy?

Population

23 consecutive patients with symptomatic extracranial internal carotid artery stenosis who were adjudicated…

Design

Cohort, open-label

Follow-up

6 months

Authors

ILItalo LinfanteBaptist Hospital of MiamiJHJoshua A HirschMassachusetts General HospitalMSMagdy SelimBeth Israel Deaconess Medical Center

Discussion

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Implication

CAS may serve as alternative for high-risk CEA candidates; leaves open whether newer stents improve outcomes versus prior generations.

Study Design

Type

Cohort (n=23)

Blinding

Open-label

Multicenter

No

Structured PICO

Does carotid angioplasty and stenting with latest-generation self-expanding stents provide a safe alternative in patients with symptomatic extracranial internal carotid artery stenosis who are ineligible for carotid endarterectomy?

P
Population
23 patients (mean age 65, 61% female) with symptomatic extracranial internal carotid artery stenosis (≥70%) ineligible for carotid endarterectomy, followed for 6 months.
I
Intervention
Carotid angioplasty and stenting (CAS) with latest-generation self-expanding stents.
O
Outcome
Death and all strokes (ipsilateral and contralateral) at 24 hours, 30 days, and 6 months.safety

Carotid angioplasty and stenting with latest-generation self-expanding stents appears to be a safe and valid alternative for patients with severe symptomatic carotid stenosis who are ineligible for endarterectomy.

Cite This Study

Linfante et al. (2004) conducted a cohort in Symptomatic extracranial internal carotid artery stenosis (≥70%) (n=23). Carotid angioplasty and stenting (CAS) with latest-generation self-expanding stents was evaluated on Death and all strokes (ipsilateral and contralateral). Carotid angioplasty and stenting with latest-generation self-expanding stents in patients ineligible for endarterectomy resulted in a 9% rate of primary adverse events (stroke or death) at 6 months.

synapsesocial.com/papers/6aa92b04e92a68cad602c271https://doi.org/10.1001/archneur.61.1.39
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictors of Stroke Complicating Carotid Artery Stenting1998 · 337 citations
  2. 2Role of the Distal Balloon Protection Technique in the Prevention of Cerebral Embolic Events During Carotid Stent Placement2001 · 100 citations