What question did this study set out to answer?

To establish a predictable, sequential one-pot catalytic protocol for carbon–heteroatom cross-coupling that installs sulfur and nitrogen groups onto (het)arene scaffolds using nickel and visible light.

October 9, 2023ACS Catalysis

Sequential One-Pot (Het)arene Thioetherification and Amination with Nickel and Visible Light

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Authors

JDJonas DükerCentre for Process Innovation IGIndrajit GhoshVSB - Technical University of Ostrava BKBurkhard KönigUniversity of Stuttgart

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Implication

Experimental study demonstrates sequential one-pot thioetherification and amination of heteroarenes using nickel photoredox catalysis, highlighting tunable synthesis routes for pharmaceutical agents.

Key Points

To establish a predictable, sequential one-pot catalytic protocol for carbon–heteroatom cross-coupling that installs sulfur and nitrogen groups onto (het)arene scaffolds using nickel and visible light.
Implemented an adaptive dynamic homogeneous catalysis (AD-HoC) platform pairing a nickel catalyst with visible-light photoredox conditions.
Conducted sequential one-pot thioetherification followed by amination across multifunctionalized (het)arene substrates, including pyrimidine scaffolds.
Enabled sequential carbon–sulfur and carbon–nitrogen bond formation within a single reaction vessel to construct diverse functionalized (het)arene libraries.
Achieved distinct, tunable regioselectivity during functionalization on pyrimidine scaffolds through photoredox-mediated condition control.

Cite This Study

Düker et al. (2023) studied this question.

synapsesocial.com/papers/6aa92c0d6db186eb9162e4be https://doi.org/10.1021/acscatal.3c03860

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Implication

Experimental study demonstrates sequential one-pot thioetherification and amination of heteroarenes using nickel photoredox catalysis, highlighting tunable synthesis routes for pharmaceutical agents.

Sequential One-Pot (Het)arene Thioetherification and Amination with Nickel and Visible Light

Discussion

Member takes

Implication

Key Points

Cite This Study

Sequential One-Pot (Het)arene Thioetherification and Amination with Nickel and Visible Light

Discussion

Member takes

Implication

Key Points

Cite This Study

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