Rapid anti-myeloma activity by T cells expressing an anti-BCMA CAR with a human heavy-chain-only antigen-binding domain

Lekha Mikkilineni; Danielle Natrakul; Norris Lam; Elisabet E. Manasanch; Jennifer Mann; Katherine A. Weissler; Nathan Wong; Jennifer N. Brudno; Stephanie L. Goff; James C. Yang; Micaela Ganaden; Rashmika Patel; Zhili Zheng; Jared J. Gartner; Kathryn R. Martin; Hao‐Wei Wang; Constance M. Yuan; Tyler Lowe; Irina Marić; Lipei Shao; Ping Jin; David F. Stroncek; Steven L. Highfill; Steven A. Rosenberg; James N. Kochenderfer

doi:10.1016/j.ymthe.2023.12.018

Abstract

FHVH-T correlated with peak blood FHVH-T levels. Single-cell RNA sequencing revealed a shift toward more differentiated FHVH-T after infusion. Anti-CAR antibody responses were detected in 4 of 12 patients assessed. FHVH-T has powerful, rapid, and durable anti-MM activity.

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Mikkilineni et al. (2023) studied this question.

synapsesocial.com/papers/6aa92ce811a60bccbd263bf5 https://doi.org/10.1016/j.ymthe.2023.12.018

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Rapid anti-myeloma activity by T cells expressing an anti-BCMA CAR with a human heavy-chain-only antigen-binding domain

Abstract

Discussion

Cite This Study

Rapid anti-myeloma activity by T cells expressing an anti-BCMA CAR with a human heavy-chain-only antigen-binding domain

Abstract

Discussion

Cite This Study

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