Key result
Cardiopulmonary exercise testing, particularly when integrated with diaphragmatic electromyography and near-infrared spectroscopy, provides mechanistic insights into the origins of unexplained chronic dyspnea.
Advanced CPET modalities offer valuable mechanistic insights to identify the etiology of unexplained chronic dyspnea, guiding targeted therapeutic interventions.
Faculty of Movement and Rehabilitation Sciences, Department of Rehabilitation Sciences, Research Group for Rehabilitation in Internal Disorders, KU Leuven, Belgium. 2. Clinical Department of Respiratory Diseases, UZ Leuven, BREATHE department CHROMETA, KU Leuven, Belgium. Dyspnea is a distressing symptom that is defined as “the subjective experience of breathing discomfort”.(1) The onset of dyspnea can be acute (during the transition from rest to physical activity) or chronic (persisting for more than one month).(1) Chronic dyspnea is one of the most common symptoms of many chronic diseases and conditions, such as cardiorespiratory diseases, cancer, and obesity, reducing exercise tolerance, physical activity levels, and health-related quality of life.(2) Epidemiological studies have estimated that 56-98% of patients with chronic respiratory diseases and 50-70% of patients with cancer complain of dyspnea, which can be the cause of up to 50% of admissions to ERs, with a peak incidence in patients between 55 and 69 years of age.(3)
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Louvaris et al. (2021) conducted an editorial in Chronic dyspnea. Cardiopulmonary exercise testing (CPET) was evaluated. Cardiopulmonary exercise testing, particularly when integrated with diaphragmatic electromyography and near-infrared spectroscopy, provides mechanistic insights into the origins of unexplained chronic dyspnea.
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