Dinemasones A, B and C – New Bioactive Metabolites from the Endophytic Fungus Dinemasporium strigosum

Two new bioactive metabolites 1a and 2a (dinemasones A, B) were isolated in pure form and one as the diacetate 3b of dinemasone C (3a) from the ethyl acetate extract of Dinemasporium strigosum together with the known palmitic acid, ergosterol and the cis and trans isomers of 4‐hydroxymellein. The structures were determined by spectroscopic analysis, notably 2D NMR techniques. Their absolute configurations were established by both their carbonyl n–π* CD transitions and the exciton chirality method of their respective dibenzoate derivatives. The dinemasones A, B (1a and 2a) showed antibacterial, antifungal, and antialgal activity.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)