Histopathological sections of wedge-biopsied liver and surgically removed gallbladder of a schistosomiasis mansoni patient were studied for the eosinophil-mediated destruction of eggs in granulomas. Apparent degranulation of eosinophils on the eggs in the granulomas and concomittant deterioration of miracidia were observed. It was construed that granule-associated enzymes may be released upon the degranulation of eosinophils, pass through the micropores of the egg shell and cause death of the miracidium inside the egg.
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Hsu et al. (1980) studied this question.