Key result
Bariatric surgery is linked to a ~36% reduction in plasma aldosterone in morbidly obese patients.
Why the study?
Renin-aldosterone-angiotensin system overactivation contributes to obesity-associated hypertension, and weight loss reduces blood pressure and RAS, but changes in plasma aldosterone concentration after bariatric surgery required investigation.
Does bariatric surgery reduce plasma aldosterone concentration in morbidly obese patients?
Cohort (n=14)
No
Does bariatric surgery reduce plasma aldosterone concentration in morbidly obese patients?
Bariatric surgery significantly reduces plasma aldosterone concentration in morbidly obese patients, which correlates with reductions in body weight and fat.
Answers are grounded in this paper and cite their sources.
Bariatric surgery-associated aldosterone reduction should not change practice; leaves open mechanistic role in obesity-related hypertension.
BACKGROUND: Overactivation of renin-aldosterone-angiotensin system (RAS) is part of the pathogenesis of obesity-associated hypertension. Evidences have shown that weight loss can result in reduction in blood pressure and RAS. This study was aim to investigate changes of plasma aldosterone concentration (PAC) after bariatric surgery. METHODS: A prospective study was done in 14 morbidly obese patients undergoing bariatric surgery. Patients who were taking medications that can interfere with PAC and renin levels were excluded. Collection of blood samples were done at baseline and at 3 and 6-month post-bariatric surgery. PAC were significantly decreased at 3-and 6-month post-bariatric surgery from 14.3 ± 8.0 to 7.5 ± 5.5 [reduction of 36% from baseline (P < 0.01)] and 8.0 ± 6.6 ng/dl [reduction of 32% from baseline (P < 0.05)] respectively. The reduction of PAC at 3-month post-surgery was correlated with the reduction of body weight (r = 0.46, P < 0.05), waist circumference (r = 0.73, P < 0.05) and percent of body fat (r = 0.58, P < 0.05). CONCLUSIONS: Maximal reduction of PAC in obese patients underwent bariatric surgery occurred during the first 3 months after bariatric surgery. The reduction of PAC was associated with the reduction of body weight, waist circumference and percent of body fat suggesting the link between RAS and obesity-mediated hypertension.
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Suwannasrisuk et al. (2020) conducted a cohort in Morbid obesity (n=14). Bariatric surgery vs. Baseline was evaluated on Plasma aldosterone concentration (PAC) at 3 months (36% reduction, p=<0.01). Bariatric surgery significantly reduced plasma aldosterone concentration by 36% at 3 months and 32% at 6 months compared to baseline in morbidly obese patients.
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