In an earlier paper (1) we confirmed the observations of Kyes and Strauser (2) with regard to the inhibitory effect of heparin on the anaphylactic syndrome. In our studies guinea pigs hypersensitive to horse serum, instead of pigeons hypersensitive to sheep serum, as used by Kyes and Strauser, were employed. In view of the failure of Hanzlik, Butt and Stockton (3), of Hyde (4), and of Reed and Lamson (5) to support our findings, we present additional data which substantiate our previous findings, using as a criterion of shock the classical symptoms of anaphylaxis. We have checked the reaction by the Dale and by the bronchospasm method of Koessler and Lewis (6). In a limited number of animals we controlled the coagulation time of the blood by means of the capillary tube method prior to the injection of the shocking dose of the antigen and also at the height of shock. These tests enable us to confirm the findings of Gahringer (7) and of Reed and Lamson (5) that there is an increased coaguabiiity of the blood at the height of shock. The average clotting time prior to shock varies between two and a half and three minutes; during shock it decreases to between thirty seconds and one minute. Peripheral blood was used for the determinations.
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Carr et al. (1928) studied this question.