Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

Migrasomes are recently discovered vesicular organelles which form on the retraction fibers (RFs) of migrating cells. 1 Once detached from cells, migrasomes can rupture and release their luminal contents 1 in a process named migracytosis. Recently, migrasomes have been shown to play an important role in zebrafish organ morphogenesis by releasing chemokine signals to defined regions of the embryo. 2 Thus, migracytosis is considered as a major mechanism for migrasomes to carry out their functions. It has been frequently observed that intact migrasomes can be engulfed by surrounding cells, 1 and this has been proposed as a potential mechanism for lateral transfer of cellular contents between cells. However, it is not clear whether the lateral transfer of cellular contents by migrasomes has functional consequences for the recipient cells.