Stevia extract was made from stevia stem by extraction with boiling water and fermentation. The protective effect of a Stevia extract on rainbow trout (average weight, 12 g) fed 1% of dietary histamine for 4 weeks was investigated. Administration of dietary histamine to trout did not result in a reduction in growth rate or feed consumption but caused a gastric abnormality, e.g. exfoliation of the mucosal epithelium and atrophy of mucosal lamina propria. Stevia extract protected gastric tissue from histamine-induced damage. Pepsin activity in gastric fluid increased and liver α-tocopherol content was reduced after histamine treatment, but Stevia treatment prevented these abnormalities. The results suggest that the stevia extract might protect the rainbow trout stomach from histamine toxicity.
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Shiozaki et al. (2004) studied this question.
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