Key result
RVOT reconstruction with stentless porcine xenografts yields a stable ~18 mmHg gradient over 2 years.
Why the study?
Does right ventricular outflow tract reconstruction with a stentless porcine aortic xenograft provide acceptable hemodynamics and clinical outcomes in patients undergoing the Ross procedure?
Observational (n=9)
Does right ventricular outflow tract reconstruction with a stentless porcine aortic xenograft provide acceptable hemodynamics and clinical outcomes in patients undergoing the Ross procedure?
A stentless porcine aortic xenograft with a pericardial roll provides acceptable mid-term hemodynamics and clinical outcomes as an alternative for RVOT reconstruction during the Ross procedure.
Hypothesis-generating for stentless xenografts in Ross RVOT reconstruction; larger prospective studies needed before wider consideration.
To investigate whether the use of a stentless porcine aortic xenograft can be an alternative for right ventricular outflow tract (RVOT) reconstruction during the Ross procedure, 9 patients underwent the Ross procedure and RVOT reconstruction with a stentless xenograft since January 2000. After the aortic valve was replaced with a pulmonary autograft, a stentless xenograft with a xeno- pericardial roll was implanted in the RVOT. One patient required subsequent aortic valve replacement because of severe regurgitation of the pulmonary autograft. All patients recovered well from the operation. The right ventricle-pulmonary arterial pressure gradient was 18 +/- 7 mm Hg at discharge and was not significantly increased during the 2-year follow-up period. Although 1 patient died of ventricular arrhythmia 5 months after, his cardiac function was normal, and transpulmonary valve pressure was 19 mm Hg in the follow-up. The other 7 patients are currently in New York Heart Association functional Class I. Although long-term follow-up is required to explain the durability, the stentless xenograft with a pericardial roll is considered to be an alternative for reconstruction of the RVOT within 2 years after the Ross procedure.
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Tsukube et al. (2002) conducted an observational in Patients undergoing Ross procedure requiring RVOT reconstruction (n=9). Stentless porcine aortic xenograft with a xenopericardial roll was evaluated on Right ventricle-pulmonary arterial pressure gradient at discharge. RVOT reconstruction with a stentless porcine aortic xenograft yielded a mean right ventricle-pulmonary arterial pressure gradient of 18 +/- 7 mm Hg at discharge, remaining stable over 2 years.
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