Key result
Global longitudinal strain was significantly lower among overweight patients with type 2 diabetes mellitus, but not among overweight individuals without diabetes.
Why the study?
Does type 2 diabetes mellitus affect global longitudinal strain in overweight patients with preserved left ventricular ejection fraction?
Does type 2 diabetes mellitus affect global longitudinal strain in overweight patients with preserved left ventricular ejection fraction?
The relationship between BMI, metabolic factors like type 2 diabetes, and left ventricular function is complex and may complicate cardiovascular risk assessment.
A recent study found that among individuals with a preserved left ventricular ejection fraction ≥ 55%, global longitudinal strain was significantly lower in overweight patients (i.e., body mass index ≥ 25 kg/m 2 ) with, but not in those without, type 2 diabetes mellitus. These results contrast previous observations of body mass index as a significant predictor of incident diastolic dysfunction and increased left ventricular mass index among subjects without prevalent diabetes. We discuss potential explanations for the observed discrepancies and general difficulties associated with cardiovascular risk assessment based on body mass index and related metabolic factors.
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Musaeus et al. (2018) conducted a letter in Type 2 diabetes mellitus and overweight (n=235). Overweight (BMI ≥ 25 kg/m2) vs. Non-overweight was evaluated on Global longitudinal strain (GLS). Global longitudinal strain was significantly lower among overweight patients with type 2 diabetes mellitus, but not among overweight individuals without diabetes.
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