The fecal hemoglobin concentration varies between colorectal pathologies and between samples because bleeding is not consistent from day to day.1 Thus, when screening for colorectal cancer (CRC) using a quantitative fecal immunochemical test (FIT), the fecal hemoglobin concentration threshold (cutoff) chosen to trigger colonoscopy,2 together with the number of stools sampled, are crucial variables requiring careful selection, because of the implications for sensitivity, specificity, colonoscopic workload, and cost effectiveness.
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Young et al. (2020) studied this question.
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