Mutations in the Plasmodium falciparum k13(Pfk13) gene are linked to delayed parasite clearance in response to artemisinin-based combination therapies (ACTs) in Southeast Asia. To explore the evolutionary rate and constraints acting on this gene,k13orthologs from species sharing a recent common ancestor with P. falciparum and Plasmodium vivax were analyzed.
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Pacheco et al. (2019) studied this question.
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