Diuretic Response to Chlorthalidone

property within the penicillin family of substances.Summary "Penbritin " has a bactericidal action, comparable to that of penicillin G upon pyogenic cocci, upon a wide range of coccal and bacillary pathogens.It is affected by penicillinase and is therefore inactive against penicillinase-forming strains of Staph.aureus and certain coliforms.Given orally in doses of 50-100 mg./kg./day, the new compound is freely absorbed and maintains a bacteri- cidal level in the plasma for four hours or more.It is rapidly excreted, in very high concentration, in the urine.Apart from transient rashes in three carriers of salmonellae, no toxic effects were observed in 28 patients who received the drug for five days or more.Eight children with severe urinary infection due to coliforms and/or streptococci responded rapidly to treatment, as did six children with other infections; six carriers of Salm.typhi-murium and two of E. coli serotypes were not cleared of infection.Penbritin warrants further trial as a bactericidal penicillin-like drug with the antibacterial range of the tetracycines.