Key result
Cross-talk between NO and H2S gasotransmitters presents unresolved chemical and biological challenges.
Why the study?
The chemical reactivities and biological effects of nitrogen and sulfur species formed by NO and H2S remain unresolved.
This review highlights the complex chemical cross-talk between NO and H2S gasotransmitters and their roles in cell signaling.
May complicate NO- or H2S-based cardiovascular interventions; leaves open key reactivities for targeted research.
S, in both chemical and biochemical contexts. Through the formation of HNO, (H)SNO (and its isomers), (H)SSNO, and polysulfides, these two gasotransmitters initiate reaction networks with significant roles in cell signaling. The chemical reactivities and biological effects of these nitrogen and sulfur species are still unresolved, and, thus, a cross-talk between all of them represents a challenging interdisciplinary field that awaits exciting new findings. We tackle some of the intriguing and open questions and provide perspectives for future research directions.
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Ivanović‐Burmazović et al. (2019) conducted a review in Cell signaling (NO and H2S cross-talk). The cross-talk between NO and H2S gasotransmitters and their reaction networks represents a challenging interdisciplinary field with unresolved chemical reactivities and biological effects.
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