Key result
Post-challenge glucose and insulin responses are strongly linked to partially oxidized LDL and sICAM-1.
Why the study?
The relationships between plasma glucose and insulin responses to oral glucose and concentrations of partially oxidized LDL and soluble intercellular adhesion molecule-1 in healthy volunteers were not well described.
Are plasma glucose and insulin responses to oral glucose correlated with LDL oxidation and sICAM-1 levels in healthy volunteers?
Observational (n=23)
Are plasma glucose and insulin responses to oral glucose correlated with LDL oxidation and sICAM-1 levels in healthy volunteers?
Effect estimate: r=0.65 (glucose) and r=0.58 (insulin)
p-value: p=<0.002 (glucose) and <0.007 (insulin)
In healthy volunteers, insulin resistance markers correlate with increased LDL oxidation and sICAM-1 levels, suggesting a mechanism for increased cardiovascular risk in insulin-resistant states.
Correlates post-challenge glucose/insulin with oxidized LDL and sICAM-1; hypothesis-generating and requires prospective validation before clinical relevance.
This study was initiated to describe the relationships between plasma glucose and insulin responses to oral glucose and the concentrations of partially oxidized low density lipoprotein (poxLDL) and soluble intercellular adhesion molecule-1 (sICAM-1) in 23 healthy, non-diabetic volunteers. Results demonstrated that plasma glucose (r=0.65, P<0.002) and insulin (r=0.58, P<0.007) responses to a 75-g oral glucose challenge were highly correlated to poxLDL concentrations. Plasma glucose (r=0.63, P<0.002) and insulin (r=0.68, P<0.001) concentrations also significantly correlated with sICAM-1 concentrations. Furthermore, concentrations of poxLDL and sICAM-1 were significantly related (r=0.55, P<0.001). These relationships remained statistically significant when adjusted for differences in age, gender, body mass index, and lipoprotein concentrations. These results provide further evidence that circulating LDL particles are more highly oxidized in insulin resistant states, and demonstrate the presence of an in vivo relationship between insulin resistance, LDL oxidized state, and sICAM-1 concentrations. These results help explain why soluble forms of adhesion molecules are increased in clinical conditions characterized by insulin resistance, and support the possibility that LDL oxidizability is increased in insulin resistant subjects, and that the increase in sICAM-1 results from stimulation of cellular adhesion molecules by more highly oxidized LDL.
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Chen et al. (2000) conducted an observational in Healthy, non-diabetic (n=23). Plasma glucose and insulin responses to oral glucose was evaluated on Correlation between plasma glucose/insulin responses and partially oxidized LDL (poxLDL) concentrations (r=0.65 (glucose) and r=0.58 (insulin), p=<0.002 (glucose) and <0.007 (insulin)). Plasma glucose and insulin responses to a 75-g oral glucose challenge were significantly correlated with partially oxidized LDL (r=0.65 and r=0.58) and sICAM-1 concentrations in healthy volunteers.
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