Key result
Circulating cardiac myosin binding protein C (cMyC) concentrations were measurable in 99.6% of participants and were associated with left ventricular remodelling and myocardial fibrosis.
Why the study?
Whether cMyC reflects chronic myocardial injury and left ventricular remodelling in the general population was unknown.
Are circulating cMyC concentrations associated with cardiovascular risk factors and imaging biomarkers of cardiac remodeling in the general population?
Cross-Sectional (n=3,672)
Are circulating cMyC concentrations associated with cardiovascular risk factors and imaging biomarkers of cardiac remodeling in the general population?
In the general population, circulating cMyC is a measurable biomarker that reflects left ventricular remodeling, focal myocardial fibrosis, and cardiac dysfunction independently of traditional risk factors.
BACKGROUND: Cardiac myosin binding protein C (cMyC) is a novel, cardiac-specific biomarker with an early release profile after acute ischemic myocardial injury. Whether cMyC reflects chronic myocardial injury and left ventricular remodelling in the general population is unknown. The aims of the study were to test the hypotheses that cMyC concentrations are associated with cardiovascular risk factors, biomarkers of chronic myocardial injury, and imaging biomarkers of cardiac anatomy, function, and fibrosis. METHODS: Circulating cMyC and cardiac troponin I and T concentrations were measured in 3672 individuals from the general population, born in 1950, who underwent echocardiography. One-hundred-ninety-nine participants with measured cMyC completed a cardiovascular magnetic resonance (CMR) examination for assessment of myocardial fibrosis. RESULTS: Circulating cMyC was measurable in 99.6% of study participants and in 99.0% of CMR substudy participants. cMyC was positively associated with left ventricular mass and left atrial volume and inversely associated with renal function and indices of left ventricular systolic and diastolic function. In participants with available late gadolinium enhancement images for the assessment of focal fibrosis (n = 197), cMyC was positively associated with indices of focal myocardial fibrosis. CONCLUSIONS: In the general population, circulating cMyC concentrations are associated with cardiovascular risk factors, reflect left ventricular remodelling, including focal myocardial fibrosis, and systolic and diastolic dysfunction independently of traditional risk factors.
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Paus et al. (2025) conducted a cross-sectional in General population (n=3,672). Cardiac myosin binding protein C (cMyC) concentrations was evaluated on Association with cardiovascular risk factors, biomarkers of chronic myocardial injury, and imaging biomarkers of cardiac anatomy, function, and fibrosis. Circulating cardiac myosin binding protein C (cMyC) concentrations were measurable in 99.6% of participants and were associated with left ventricular remodelling and myocardial fibrosis.
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