H 2 O 2 -triggered release of CO: an intratumoral H 2 O 2 -responsive nanomedicine is constructed by effectively encapsulating the hydrophilic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize selective killing of tumor cells, exhibiting high in vitro and in vivo efficacies of CO gas therapy.
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Jin et al. (2017) studied this question.
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