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September 4, 2018Science SignalingOpen Access

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

Akshay A. D’Cruz Mary Speir Meghan Bliss‐Moreau Sylvia Dietrich Shu Wang Alyce A. Chen Mathilde Gavillet Arshed Al‐Obeidi Kate E. Lawlor James E. Vince Michelle A. Kelliher Razqallah Hakem Manolis Pasparakis David A. Williams Maria Ericsson Ben A. Croker

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Abstract

RIPK1-dependent necroptotic cell death stimulates neutrophil NET formation to control MRSA infection.

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Cite This Study

D’Cruz et al. (2018) studied this question.

synapsesocial.com/papers/6aa934aedf41e3f51602cacd https://doi.org/10.1126/scisignal.aao1716

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Rapid Pathogen-Induced Apoptosis: A Mechanism Used by Dendritic Cells to Limit Intracellular Replication of Legionella pneumophilaOriginal Research · 2009 · 104 citations
2Cytomegalovirus M45 Cell Death Suppression Requires Receptor-interacting Protein (RIP) Homotypic Interaction Motif (RHIM)-dependent Interaction with RIP1Original Research · 2008 · 202 citations
3Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic mannerOriginal Research · 2017 · 482 citations
4RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKLOriginal Research · 2015 · 650 citations
5Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell deathOriginal Research · 2014 · 598 citations

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates2014
Necroptosis induced by RIPK3 requires MLKL but not Drp12014
The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages2015
Neuronal tRNA modifications in Aplysia californica are repatterned during behavioral habituationScience Signaling · 2026
Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasmScience Signaling · 2026

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