AIMTo perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal adenoma. METHODSPubMed and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-a) and risk of colorectal adenoma.Random-effects models were used to calculate summary odds ratios (ORs) with 95%CIs for the highest vs lowest category of exposure.Heterogeneity was assessed by using the Q test and I 2 statistic.Subgroup analyses were also performed to test for potential source of heterogeneity.
No takes yet. Share an insight, caveat, or question.
Godos et al. (2017) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: