Key result
Elevated soluble semaphorin 4D reflects inflammatory status in STEMI patients better than hs-CRP.
Why the study?
The study sought to investigate soluble semaphorin 4D (sSema4D) expression in acute STEMI and explore its value in evaluating the inflammatory status of acute myocardial infarction.
Does serum sSema4D level better reflect the inflammatory state of acute ST-segment elevation myocardial infarction compared to hs-CRP?
Observational (n=261)
No
Does serum sSema4D level better reflect the inflammatory state of acute ST-segment elevation myocardial infarction compared to hs-CRP?
Effect estimate: AUC 0.780 (95% CI 0.629-0.837)
p-value: p=<0.001
Serum sSema4D levels are significantly elevated in STEMI patients and may serve as a better biomarker for inflammatory status than traditional indicators like hs-CRP.
sSema4D may better reflect STEMI inflammation than hs-CRP; leaves open clinical utility pending prospective validation.
Background: This study sought to investigate the expression of soluble semaphorin 4D (sSema4D) in acute ST-segment elevation myocardial infarction (STEMI) and to explore its value in evaluating the inflammatory status of acute myocardial infarction (AMI). Methods: From October 2020 to June 2021, 100 patients with STEMI diagnosed at the Department of Cardiology of our hospital were selected as the STEMI group, 83 patients with unstable angina (UA) were selected as the UA group, and 78 patients with negative coronary angiography (CAG) were selected as the control group. The baseline data of the 3 groups of patients were recorded, the sSema4D levels were determined, the expression of sSema4D levels in AMI was analyzed, and the value of sSema4D levels in reflecting inflammatory state of AMI was explored. Results: Compared with UA group and control group, the expression of sSema4D in peripheral blood of STEMI group was significantly increased (P<0.001), which could better reflect the inflammatory status of patients with STEMI than traditional inflammatory indicators [hypersensitive c-reactive protein (hs-CRP)] (P<0.05). The receiver operating characteristic (ROC) curve showed that sSema4D (AUC =0.780, cut-off =19.62, 95% CI: 0.629, 0.837, P<0.001) was more specific than hs-CRP (AUC =0.697, cut-off =3.39, 95% CI: 0.629, 0.765, P<0.001) in reflecting the inflammatory status of STEMI patients. Conclusions: sSema4D levels have certain value in reflecting the inflammatory state of STEMI.
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Zheng et al. (2023) conducted an observational in acute ST-segment elevation myocardial infarction (STEMI) (n=261). Soluble semaphorin 4D (sSema4D) vs. Unstable angina and negative coronary angiography was evaluated on Inflammatory status of STEMI patients (diagnostic accuracy) (AUC 0.780, 95% CI 0.629-0.837, p=<0.001). Soluble semaphorin 4D levels were significantly elevated in STEMI patients and reflected inflammatory status better than hs-CRP (AUC 0.780; 95% CI 0.629-0.837; P<0.001).
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