Strategies towards Chemoselective Suzuki–Miyaura Cross-Coupling

Chemoselective Suzuki–Miyaura cross-coupling has emerged as a powerful method for the rapid preparation of sp 2 - and sp 3 -hybridized carbon frameworks based on control of the oxidative addition or transmetalation events. The field of chemoselective transmetalation has recently seen considerable development with several different strategies emerging including protected boronic acids, neighboring-group activation, and chemoselective speciation. Herein, these state-of-the-art approaches towards chemoselective Suzuki–Miyaura cross-coupling are highlighted. 1 Chemoselective Suzuki–Miyaura Cross-Coupling via Control of Oxidative Addition 2 Chemoselective Suzuki–Miyaura Cross-Coupling via Control of Transmetalation 3 Development and Use of BMIDA Reagents 4 Development and Use of BDAN Reagents 5 Use of Vicinal and Geminal Diboron Species in Chemoselective Cross-Coupling 6 Controlling Boron Solution Speciation 7 Summary