Methodological Biases in CBT Trial—Commentary: Modular Cognitive-Behavioral Therapy for Affective Symptoms in Young Individuals at Ultra-High Risk of First Episode of Psychosis: Randomized Controlled Trial

Preventive interventions in individuals at clinical high risk for psychosis (CHR-P) are the mainstream approach to improve outcomes of the most severe mental disorder (1).Recent independent network (2, 3) or pairwise meta-analyses (4) converged indicating that there is no evidence to favour the recommended first-line treatment-Cognitive Behavioural Therapy, CBTover other interventions (including needs-based-interventions) for the prevention of psychosis in CHR-P populations.Since the meta-analytical confidence interval of these estimates is large, there is high uncertainty (5) and future randomised controlled trials (RCT) are thus expected to have a major impact on the level of the evidence.The article by Pozza and Dèttore (6) published in the past month, reports a new RCT of CBT for CHR-P individuals, which concluded in the abstract that CBT "can prevent psychosis risk and