Key result
Citric acid-coated nanoparticles plus anthracyclines boost DNA incorporation and inhibit cell growth in vitro.
Why the study?
A novel method to enhance the anticancer activity of anthracyclines in vitro using hydrophilic magnetic nanoparticles was proposed.
Does nano-Fe3O4-CA combined with anthracyclines improve cytotoxicity in vitro compared to anthracyclines alone?
Does nano-Fe3O4-CA combined with anthracyclines improve cytotoxicity in vitro compared to anthracyclines alone?
Citric acid-coated magnetite nanoparticles enhance the in vitro cytotoxicity of anthracyclines, potentially allowing for dose reduction.
May enhance anthracycline cytotoxicity via nanoparticles in vitro; leaves open in vivo efficacy and clinical translation.
A novel method for enhancing the anticancer activity of anthracyclines in vitro was proposed by using hydrophilic magnetic nanoparticles. Citric acid-coated magnetite nanoparticles Fe3O4 (nano-Fe3O4-CA) interacted with anthracyclines by electrostatic and hydrophobic forces, resulting in the formation of aggregates (nano-Fe3O4-CA-drug). The aggregate was studied by resonance light scattering and fluorescence spectroscopy. The results indicated that in comparison with anthracyclines, the nano-Fe3O4-CA-drug showed high activity towards incorporation in the DNA chain. Furthermore, the cytotoxicity of nano-Fe3O4-CA-drug was investigated by cytotoxicity experiment and cell morphology study. The results confirmed that the nano-Fe3O4-CA-drug could inhibit the growth of cells more effectively than the drug alone. In conclusion, usage of nano-Fe3O4-CA affords reduction of the dosage of anthracyclines in vitro.
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Yang et al. (2016) studied Cancer. Citric acid-coated magnetite nanoparticles Fe3O4 with anthracyclines (nano-Fe3O4-CA-drug) vs. Anthracyclines alone was evaluated on Cytotoxicity and incorporation in the DNA chain. Citric acid-coated magnetite nanoparticles combined with anthracyclines showed higher incorporation into DNA and more effectively inhibited cell growth in vitro compared to the drug alone.
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