Effect of Clopidogrel Combined with Atorvastatin on Serum Lipids, Inflammatory Factors and Cardiac Function Parameters in Patients with Angina Pectoris and Coronary Heart Disease

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Gastric cancer (n=133). Intervention: CDX1 and CDX2 gene expression and promoter methylation vs. Normal tissues adjacent to the tumor and normal controls. Primary outcome: Promoter methylation and expression of CDX1 and CDX2 genes.

Q: What does this research mean for the field?

Changes in CDX1 and CDX2 gene expression significantly associate with advanced disease stage and vascular/perineural invasion in gastric cancer, though CDX1 promoter methylation alone is insufficient as a poor prognostic biomarker. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jiaojiao Ma

doi:10.17582/journal.pjz/20230816081639

January 1, 2024Pakistan Journal of ZoologyOpen Access

Effect of Clopidogrel Combined with Atorvastatin on Serum Lipids, Inflammatory Factors and Cardiac Function Parameters in Patients with Angina Pectoris and Coronary Heart Disease

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Why the study?

Gene promoter methylation changes are considered a suitable target for therapeutic strategies, motivating investigation of CDX1 and CDX2 promoter methylation and expression in Chinese patients with gastric cancer.

Study Design

Type

Observational (n=133)

Structured PICO

P

Population

133 tissue samples from Chinese patients with gastric cancer analyzed for CDX1 and CDX2 gene promoter methylation and expression.

C

Comparator

Normal tissues adjacent to the tumor and normal controls

O

Outcome

Promoter methylation and expression of CDX1 and CDX2 genessurrogate

Implication

Changes in CDX1 and CDX2 gene expression, rather than promoter methylation, are associated with advanced disease stages and invasion in gastric cancer.

Discussion

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Cite This Study

Jiaojiao Ma (2024) conducted an observational in Gastric cancer (n=133). CDX1 and CDX2 gene expression and promoter methylation vs. Normal tissues adjacent to the tumor and normal controls was evaluated on Promoter methylation and expression of CDX1 and CDX2 genes.

synapsesocial.com/papers/6aa93849df41e3f51602cc1f https://doi.org/10.17582/journal.pjz/20230816081639

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PCSK9 inhibitors

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Effect of Clopidogrel Combined with Atorvastatin on Serum Lipids, Inflammatory Factors and Cardiac Function Parameters in Patients with Angina Pectoris and Coronary Heart Disease

Study Design

Structured PICO

Implication

Discussion

Cite This Study

Topics

Effect of Clopidogrel Combined with Atorvastatin on Serum Lipids, Inflammatory Factors and Cardiac Function Parameters in Patients with Angina Pectoris and Coronary Heart Disease

Study Design

Structured PICO

Implication

Discussion

Cite This Study

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Topics

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