Renal clearance and plasma protein binding of oxytetracycline in man

The clearance of oxytetracycline was measured in eight children, four of whom also received glucosamine. The average clearance of oxytetracycline was 163.7 ml/min./1.73 m2 in the eight experiments and the average clearance of inulin was 115.8 ml/min/1.73 m2. About two-thirds of the oxytetracycline appearing in the urine was filtered at the glomeruli. One-third was secreted by the tubules. About three-fourths of the oxytetracycline in human plasma was found to be dialyzable and one-fourth bound to protein. Glucosamine (40 mg/kg) administered for 24 hours did not significantly modify the renal tubular secretion of oxytetracycline. Note: (With Technical Assistance by S. Graziano and R.