Background and Objectives: Formal genetics of ABO, H‐h and Se‐se systems illustrate that these three systems are genetically independent Materials and Methods: Population analysis of phenotypes and family segregation of the ABH related genetic markers Results: Inactivating mutations of FUT1 and FUT2 are compatible with a structural gene model assuming that FUT1 and FUT2 genes encode for two distinct enzymes, one encoding for the H antigen expressed in red cells (FUT1) and the other encoding for the H gene expressed in saliva (FUT2) Conclusion: Most inactivating mutations of FUT1 and FUT2 genes are located in the coding region of the genes and are nonprevalent sporadic mutations of relative recent appearance
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Oriol et al. (2000) studied this question.
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