The development of a pilot process for the enantioselective hydrogenation of 3,5-bistrifluoromethyl acetophenone (BTMA) using a Ru/phosphine−oxazoline complex in toluene in the presence of aqueous NaOH is described. Various reaction parameters and quality risk factors such as ligand structure, substrate quality, reaction conditions, thermal safety, etc. were investigated. The reaction was carried out twice on a 140-kg scale at 20 bar and 25 °C with substrate-to-catalyst ratios of 20,000 with an enantiomeric excess of >95%. After crystallization, ( R )-3,5-bistrifluoromethyl phenyl ethanol (BTMP) was obtained with an ee between 97.7 and 98.6% in 70% chemical yield.
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Naud et al. (2007) studied this question.
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