PIFA-mediated cyclization of methyl(2-(1-phenylvinyl)phenyl)sulfane for the concise, flexible, and scalable de novo synthesis of C3-arylated benzo[ b ]thiophenes

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This work presents an efficient PIFA-mediated cyclization for synthesizing C3-arylated benzo[ b ]thiophenes, which are crucial in medicinal chemistry, while bypassing traditional sulfoxide intermediate formation via a novel thionium complex pathway.