Streptomyces griseus (ATCC 10137) and Streptomyces catenulae (ATCC 23893) were used to convert genistein 5,7,4‘-trihydroxyisoflavone ( 1 ) a major isoflavone found in soybeans, into five metabolites, four of which were previously unknown. These were 5,7,3‘,4‘-tetrahydroxy-8-methylisoflavone ( 3 ), 5,7,3‘,4‘-tetrahydroxy-8-methylisoflavanone ( 4 ), 5,7,4‘-trihydroxy-3‘-methoxyisoflavone ( 5 ), 5,7,8,3‘,4‘-pentahydroxyisoflavone ( 7 ), and the known compound, 5,7-dihydroxy-3‘,4‘-dimethoxyisoflavone ( 6 ). Identities of these metabolites were established by HRFABMS and 1D and 2D NMR correlation spectroscopy.
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Hosny et al. (1999) studied this question.
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