Key result
Oleic acid injection markedly increases single-unit activity of pulmonary nociceptors.
Why the study?
Does oleic acid-induced acute lung injury activate pulmonary nociceptors in rabbits?
Population
Anaesthetized, open-chest, mechanically ventilated rabbits
Comparison
Oleic acid injection (75 microl kg i.v.) to… vs Baseline (before injection)
Design
Preclinical
Follow-up
90 min
Authors
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May implicate pulmonary nociceptors in experimental acute lung injury responses; hypothesis-generating for human translation.
Does oleic acid-induced acute lung injury activate pulmonary nociceptors in rabbits?
p-value: p=<0.05
Acute lung injury induced by oleic acid stimulates pulmonary nociceptors, which may play a role in pathophysiological respiratory responses.
Lin et al. (2007) studied Acute lung injury (n=8). Oleic acid injection vs. Baseline (before injection) was evaluated on Single-unit activity of C fibre receptors (CFRs) and high-threshold Adelta fibre receptors (HTARs) (p=<0.05). Oleic acid injection significantly increased single-unit activity of pulmonary nociceptors, from 0.3 to 1.4 impulses/s for CFRs and from 0.5 to 1.7 impulses/s for HTARs (P<0.05).
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