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Develop and validate a cell-permeable, high-affinity fluorescent probe platform to detect cannabinoid receptor type 2 and track its dynamics in living biological models.

January 1, 2022Chemical ScienceOpen Access

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

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Develop and validate a cell-permeable, high-affinity fluorescent probe platform to detect cannabinoid receptor type 2 and track its dynamics in living biological models.
Designed a highly potent, cell-permeable fluorescent probe targeted specifically to cannabinoid receptor type 2.
Employed the probe in live native cells and live zebrafish models to evaluate receptor labeling and dynamic trafficking.
The fluorescent probe demonstrated high-affinity binding and successful visualization of cannabinoid receptor type 2 in native cells.
Live-cell and in vivo imaging in zebrafish confirmed effective cell permeability and real-time tracing of receptor trafficking.

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Implication

Experimental study demonstrates real-time visualization of cannabinoid receptor type 2 in living cells and zebrafish, suggesting a powerful tool for monitoring receptor trafficking.

Cite This Study

Gazzi et al. (2022) studied this question.

synapsesocial.com/papers/6aa93e79f89f50ab9e62e568 https://doi.org/10.1039/d1sc06659e

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Implication

Experimental study demonstrates real-time visualization of cannabinoid receptor type 2 in living cells and zebrafish, suggesting a powerful tool for monitoring receptor trafficking.

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

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Discussion

Implication

Cite This Study

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

Key Points

Discussion

Implication

Cite This Study

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