Reglid: novel glycolipids from Korean red ginseng marc

Background: Ginseng contains ginseng saponins as well as non-saponin components. In a previous study, we introduced a bioactive glycolipoprotein complex called gintonin, which play as a lysophosphatidic acid (LPA) receptor ligand. However, until now new ingredient(s) have not been discovered, except for gintonin. The purpose of this study is to further identify and isolate novel bioactive component(s). Methods: Reglid biological effects on skin cell proliferation, autophagy activity, wound healing and melanin formations. Results: studies showed that Reglid treatment increases skin cell proliferation in human dermal fibroblasts, promotes wound healing in HaCaT cells, and enhances autophagy activity in human skin fibroblasts. Reglid treatment also inhibits melanin production by inhibiting tyrosinase activity in melanoma cells. Conclusion: The present study provides a novel discovery of Reglid, a group of bioactive glycolipids containing LPC, PC, and carbohydrates derived from KRGM, and shows its potential application in cosmeceutical products for functional skin health. Finally, KRGM is a resource for KRGM-derived Reglid preparations.