What question did this study set out to answer?

The PROUDEST study aims to investigate the effects of SARS-CoV-2 infection during pregnancy on maternal health, delivery, and puerperium, as well as its long-term impact on offspring growth, metabolism, and neurodevelopment up to 5 years of age.

February 25, 2021JMIR Research ProtocolsOpen Access

Pregnancy Outcomes and Child Development Effects of SARS-CoV-2 Infection (PROUDEST Trial): Protocol for a Multicenter, Prospective Cohort Study

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The PROUDEST study aims to investigate the effects of SARS-CoV-2 infection during pregnancy on maternal health, delivery, and puerperium, as well as its long-term impact on offspring growth, metabolism, and neurodevelopment up to 5 years of age.
Multicenter, prospective cohort study (Brazilian Register of Clinical Trials RBR65QXS2) structured into two sequential substudies: PREGNANT and BORN.
The PREGNANT substudy evaluates pregnant women aged 18–40 years with laboratory-confirmed SARS-CoV-2 infection (n=300) against unexposed controls (n=300) to examine inflammatory and immunological mechanisms.
The BORN substudy monitors the exposed offspring (n=300) and unexposed controls (n=300) from birth to age 5 to assess growth, metabolism, and neurodevelopment.
Recruitment commenced in July 2020; as of January 2021, 260 pregnant women with SARS-CoV-2 infection and 160 newborns have been enrolled.
Final data analysis is planned upon complete data collection to inform clinical management protocols and public health recommendations for exposed mothers and their children.

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Implication

Prospective cohort study reports maternal and child health outcomes in gestational SARS-CoV-2 infection, highlighting long-term immunological and developmental implications.

Cite This Study

Fernandes et al. (2021) studied this question.

synapsesocial.com/papers/6aa93eb623db11feac87898b https://doi.org/10.2196/26477

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Implication

Prospective cohort study reports maternal and child health outcomes in gestational SARS-CoV-2 infection, highlighting long-term immunological and developmental implications.

Pregnancy Outcomes and Child Development Effects of SARS-CoV-2 Infection (PROUDEST Trial): Protocol for a Multicenter, Prospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

Pregnancy Outcomes and Child Development Effects of SARS-CoV-2 Infection (PROUDEST Trial): Protocol for a Multicenter, Prospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

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