Multidisciplinary management of neurological disorders: Roles of pharmacotherapy, nutritional support, and manual therapy

Neurological disorders are one of the major causes of long-term disability, functional impairment, and reduced quality of life among different groups of people. Modern evidence suggests that the optimal management should go beyond disease-specific therapy and include multidisciplinary care. This narrative review will critically synthesize the evidence to identify the interactive roles of pharmacological management, nutritional optimization, and manual rehabilitative interventions in influencing functional recovery in neurological disorders. The structured narrative methodology was chosen, and peer-reviewed articles were identified through database searches in Scopus, PubMed, Web of Science, and Google Scholar, with publications between 2000 and 2025. The reviewed literature supports the evidence that pharmacological therapies are central to stabilizing neurological pathology and managing symptoms, including spasticity, neuropathic pain, and motor dysfunction. It has been demonstrated that nutritional modulation aids neuroplasticity, minimizes inflammatory mechanisms, and improves metabolic capacity for rehabilitation. Furthermore, when used as part of multidisciplinary care pathways, manual rehabilitation methods can be useful for treating secondary musculoskeletal complications, optimizing joint movement, reducing pain, and supporting participation in functional rehabilitation. Together, these therapeutic applications can be used in a coordinated manner to potentially improve responsiveness to rehabilitation and yield better functional recovery trajectories in neurological populations. The results emphasize the need to consider integrated rehabilitation models that combine medical, nutritional, and rehabilitative approaches. The next step in research should focus on rigorous clinical trials of integrated rehabilitation models and long-term functional outcomes to enhance evidence-based, multidisciplinary neurological care.