Key result
Poor mental health before AMI linked to ~261% higher all-cause mortality.
Why the study?
The etiology of acute myocardial infarction in patients without standard modifiable cardiovascular risk factors remains unclear, while mental health status may contribute to pathogenesis and worsen outcomes.
Does poor mental health status predict the occurrence of SMuRF-less AMI and increase all-cause mortality in patients with AMI?
Population
650 consecutive patients with AMI and pre-AMI mental health status data
Comparison
Poor mental health status (MCS ≤ 50) vs good mental health status (MCS > 50) across SMuRF status
Design
Prospective cohort study analysis
Authors
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Poor pre-AMI mental health flags higher mortality risk; hypothesis-generating for screening trials, should not yet change practice.
Cohort (n=650)
Yes
Does poor mental health status predict the occurrence of SMuRF-less AMI and increase all-cause mortality in patients with AMI?
Hazard Ratio: 3.61 (95% CI 2.02–6.43)
Absolute Event Rate: 17.4% vs 5%
p-value: p=<0.01
Poor mental health status is highly prevalent in patients with SMuRF-less AMI and serves as an independent predictor of both the occurrence of SMuRF-less AMI and subsequent all-cause mortality.
Moysidis et al. (2025) conducted a cohort in Acute myocardial infarction (n=650). Poor mental health status (MCS ≤ 50) vs. Good mental health status (MCS > 50) was evaluated on All-cause mortality (aHR 3.61, 95% CI 2.02-6.43, p=<0.01). Poor mental health status prior to acute myocardial infarction was associated with a significantly higher risk of all-cause mortality compared to good mental health status (aHR 3.61).
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