Key result
Citrus sinensis and Vitis vinifera mixture reduces doxorubicin-induced cardiomyocyte damage without compromising breast cancer apoptosis.
Why the study?
There is growing interest in nutraceuticals capable of counteracting chemotherapy side effects in current chemotherapeutic protocols.
Does a mixture of Citrus sinensis and Vitis vinifera prevent doxorubicin-induced oxidative stress in embryonic cardiomyocytes and breast cancer cells?
Does a mixture of Citrus sinensis and Vitis vinifera prevent doxorubicin-induced oxidative stress in embryonic cardiomyocytes and breast cancer cells?
A 1:1 mixture of Citrus sinensis and Vitis vinifera extracts protects cardiomyocytes from doxorubicin-induced damage in vitro without compromising the drug's efficacy against breast cancer cells.
Hypothesis-generating for cardioprotection during doxorubicin therapy; leaves open clinical translation from this in vitro model.
The interest towards nutraceuticals able to counteract drug side effects is continuously growing in current chemotherapeutic protocols. In the present study, we demonstrated that smoothies containing mixtures of Citrus sinensis and Vitis vinifera L. cv. Aglianico N, two typical fruits of the Mediterranean diet, possess bioactive polyphenols that protect cardiomyocytes against doxorubicin-induced oxidative stress. The polyphenolic extracts isolated from Citrus sinensis- and Vitis vinifera-based functional smoothies were deeply characterized by Liquid Chromatography-Mass Spectrometry methods. Subsequently, the functional smoothies and relative mixtures were tested to verify their ability to affect cellular viability and oxidative stress parameters in embryonic cardiomyocyte cells (H9c2), and human breast adenocarcinoma cell line (MCF-7) exposed to doxorubicin. Interestingly, we found that the mix resulting from Citrus sinensis and Vitis vinifera association in ratio 1:1 was able to reduce cardiomyocytes damage induced by anthracyclines, without significantly interfering with the pro-apoptotic activity of the drug on breast cancer cells. These results point out the potential use of vegetable smoothies as adjuvants functional foods for chemotherapeutic anticancer protocols.
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Pepe et al. (2020) studied Doxorubicin-induced oxidative stress. Citrus sinensis and Vitis vinifera smoothies was evaluated on Cellular viability and oxidative stress parameters. A 1:1 mixture of Citrus sinensis and Vitis vinifera reduced doxorubicin-induced cardiomyocyte damage without interfering with the drug's pro-apoptotic activity on breast cancer cells.
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