Lupeol and crotocorylifuran from Nigerian Croton gratissimus: Unlocking potent bioactive compounds

InformationIn this study, the phytochemical analysis of the stem bark and root of Croton gratissimus was conducted to isolate bioactive compounds.The plant materials were collected and extracted using dichloromethane (CH2Cl2) and methanol (MeOH).The results showed that the C. gratissimus root and stem bark extracts contained important phytochemicals and were active in DPPH and cytotoxicity assay.The column chromatography yielded lupeol and crotocorylifuran according to the NMR spectroscopy and literature reports.Specifically, two bioactive compounds lupeol and crotocorylifuran were isolated from the root and stem bark of Croton gratissimus.The compound crotocorylifuran was reported for the first time in C. gratissimus.