A new method for the synthesis of homoschizokinen 1 and schizokinen 2 is described. 2‐tert‐Butyl‐1,3‐di‐N‐hydroxysuccinimidyl citrate has been applied as the key substrate. The method excludes the possibility of imide formation. The imide of compound 1 has been obtained analogously from the active ester of the 1,3‐dioxolan‐4‐one derivative 5 . It has been stated that 13 C‐n.m.r. signals of the C‐3 carbon atoms enable the detection of traces of homoschizokinen 17 .
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Milewska et al. (1987) studied this question.
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