Key result
Combined IL-6, TNF-a, and iFABP predicts post-stroke depression with ~0.93 AUC, outperforming individual biomarkers.
Why the study?
The study was conducted to investigate the expression levels of blood biomarkers IL-6, TNF-a, and iFABP in patients with post-stroke depression, and their correlation with post-stroke depression occurrence.
Does the combined detection of blood biomarkers IL-6, TNF-a, and iFABP predict the occurrence of post-stroke depression in stroke patients?
Observational (n=299)
No
Does the combined detection of blood biomarkers IL-6, TNF-a, and iFABP predict the occurrence of post-stroke depression in stroke patients?
Combined detection of blood biomarkers IL-6, TNF-a, and iFABP may serve as an effective predictor for the occurrence of post-stroke depression.
Biomarker elevations were associated with PSD; leaves open predictive utility and need for prospective validation before clinical adoption.
Background: To investigate the expression levels of blood biomarkers interleukin-6 (IL-6), tumour necrosis factor (TNF-a), and intestinal fatty acid binding protein (iFABP) in patients with post-stroke depression (PSD), and their correlation with PSD occurrence. Methods: Clinical data of stroke patients admitted to the First People's Hospital of Wenling from December 2017 to December 2022 were retrospectively analyzed. Patients were classified into two groups based on their Hamilton Depression Rating Scale (HAMD) scores: PSD and nonPSD groups. The blood levels of IL-6, TNF-a, and iFABP were compared between the two groups, and their association with PSD occurrence was analyzed. Results: The PSD group had significantly higher levels of IL-6, TNF-a, and iFABP. The combined detection of these biomarkers demonstrated a greater predictive value for PSD occurrence compared to the individual detection of each biomarker. Conclusions: The study indicates that the levels of IL-6, TNF-a, and iFABP in the blood are significantly increased in patients with PSD. The combined detection of these biomarkers can effectively predict the occurrence of PSD, indicating high clinical value.
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Wang et al. (2023) conducted an observational in Post-stroke depression (n=299). Elevated blood biomarkers (iFABP, IL-6, and TNF-a) vs. Lower biomarker levels (non-PSD stroke patients) was evaluated on Occurrence of post-stroke depression (iFABP predictor in multivariable model) (OR 1.27, 95% CI 1.11-1.44, p=<0.001). The combined detection of blood biomarkers IL-6, TNF-a, and iFABP effectively predicted the occurrence of post-stroke depression with an AUC of 0.933, outperforming the predictive value of any individual biomarker.
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