Significant involvement of CCR2–64I and CXCL12–3a in the development of sporadic breast cancer

DNA extraction and genotyping DNA extraction was carried out according to previously published methods. 14All specimens were examined for the presence of amplifiable DNA.In each PCR, two negative Key points N The CCR2-64I allele conferred significant protection from breast cancer.N The mutated CXCL12 allele conferred increased susceptibility to breast cancer.N Polymorphisms in the CCR5 gene (D32, 59029 G-A) showed no association with breast cancer.N No association was found in the bladder and skin cancer groups with any of the chemokine polymorphism studied.1 of 5 www.jmedgenet.com