Parotid Gland Injections of Botulinum Toxin A Are Effective in Treating Sialorrhea in Amyotrophic Lateral Sclerosis

OBJECTIVE: : The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis. MATERIALS AND METHODS: : Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A. RESULTS: : No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most. CONCLUSIONS: : Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.