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September 15, 2026SeparationsOpen Access

Comparative Volatile Profiles and Biological Activities of Methanol and Ethyl Acetate Extracts of Two Endemic Origanum Species from Türkiye

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Authors

ACAhmet Ozan CengizYKYavuz Bülent KöseBMBilge Nur MUTLU

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Overview

Comparative in vitro study reveals ethyl acetate extracts of endemic Origanum species possess potent antimicrobial and cytotoxic effects against cancer cells, indicating solvent-dependent...

Key Points

  • To systematically compare the volatile profiles and evaluate the comparative antimicrobial and cytotoxic activities of methanol and ethyl acetate extracts from two endemic Origanum species.
  • Extracted essential oils via hydrodistillation and analyzed volatile constituents using GC-FID and GC-MS.
  • Evaluated antimicrobial activity of methanol and ethyl acetate extracts against multiple microorganisms using the broth microdilution assay.
  • Assessed cytotoxicity and selectivity against A549 lung cancer, MCF-7 breast cancer, and NIH/3T3 non-tumorigenic cell lines using the MTT assay.
  • Both essential oils displayed p-cymene-rich profiles with varying proportions of γ-terpinene (3.1–24.4%), thymol (4.0–18.2%), borneol (0.6–15.6%), linalool (0.1–10.4%), and carvacrol (0.1–3.4%).
  • Ethyl acetate extracts demonstrated superior antimicrobial potency with MIC values of 125–250 µg/mL compared to 500–1000 µg/mL for methanol extracts against responsive microorganisms.
  • Ethyl acetate extracts produced the strongest cytotoxicity across tested cell lines (IC50 6.74–14.49 µg/mL), with Origanum saccatum ethyl acetate extract exhibiting the highest selectivity toward MCF-7 cells (selectivity index of 3.176).

Cite This Study

Cengiz et al. (2026) studied this question.

synapsesocial.com/papers/6aa94e6a9013453be30a260bhttps://doi.org/10.3390/separations13090260
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