Hydroaminomethylation of 1-octene and piperidine has been carried out using a pyrrole-substituted phosphine ligand (see Scheme; L), giving extremely high activities (TOF≈6200 h−1) and selectivities (linear/branched ratios>200). Acidic alcohols in the solvent mixture lead to higher activities but lower selectivities, whereas less acidic alcohols give extraordinarily good selectivities.
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Hamers et al. (2009) studied this question.
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